Marković B
MarkovićB., ENT department G.H. Medigroup, Belgrade
Title: Sensitivity and specificity of tests (number of eosinophils in the nasal secretion and total number of eosinophils in the blood), in the diagnosis and monitoring of the effect of intranasal corticosteroid therapy in patients with allergic rhinitis
Biography:
Abstract:
Allergic rhinitis is one of the most common chronic respiratory diseases, with an increase in prevalence, a negative impact on daily activities, sleep disturbance, and a steady increase in associated diseases such as asthma. Allergic rhinitis is a much more complex problem than the classic symptoms that accompany it. Its negative impact on daily activities and sleep in adults and children has been proven. According to epidemiological studies, 15-30% of adults and 40% of children worldwide suffer from allergic rhinitis. Compared to twenty years ago, the number of patients has almost doubled with a tendency for further growth. The aim of our study is to determine whether determining the number of eosinophils in the nasal secretion and the total number of eosinophils in the blood, are reliable and useful diagnostic procedures in diagnosing allergic rhinitis and monitoring the effect of treatment with intranasal corticosteroids. The study included 60 patients with allergic and non-allergic rhinitis. Patients were divided into two groups of 30 subjects. A prospective study was conducted, case series, in season, from 01.08.2014. until 31.07.2015. to cover all three significant pollinations: trees (mid-February to early May), grass (May to mid-July), weeds (mid-May to November) and year-round mite allergen. The examination was conducted at Kikinda General Hospital. The diagnosis of allergic rhinitis was made on the basis of history, clinical presentation and results of in-vivo diagnostic tests. The sensitivity and specificity of the tests were 80% and 100% for the number of eosinophils in the nasal secretion and the number of eosinophils in the blood. Differences in pre-therapeutic and post-therapeutic values of eosinophils were statistically significant (p <0.05).Conclusion: Within the test sample we have shown that tests, determination of the number of eosinophils in the nasal secretion and the total number of eosinophils in the blood, have high specificity and sensitivity and can be used in everyday practice.